AI-Enabled Screening Workflows
Learn how to make the most of AI-derived tags in MLM-AI
Biologit MLM-AI supports various strategies that leverage AI to focus screening efforts on the results more likely to contain relevant information. This document presents an outline of AI-based screening strategies with examples.
Results created in Biologit MLM-AI may receive one or more AI tags representing the predictions of AI models mapping to various aspects of safety surveillance workflows: potential safety events, special situations, and identifiable patients.
The diagram below illustrates how AI tags helps users focus on the most relevant results for safety surveillance:
The following AI Tags are available in MLM-AI:
The abstract or full text may contain the description of an adverse event. Thus, MLM-AI flagged the abstract as a candidate for further screening.
The abstract or full text may contain the description of a case (identifiable patient).
The abstract describes animal or in-vitro studies.
Any detected special situation (elderly, pediatric, pregnancy) is also flagged as a tag.
A confirmed patient mention (ex: "a 72-year old woman" etc)
With AI tags, users can:
- Prioritize abstracts classified as Suspected AE, by ranking or filtering results.
- Use less resource intensive screening methods where safety events are unlikely. For example:
Ensure automated screening using AI Tags is implemented with adequate risk-based quality controls in place for your scenario. Batch Review and Sampled QC can help with your requirements.
This section contains examples of how to employ AI tags for faster screening.
Abstracts in a review can be ranked according to their AI Tags. In the Reviews page simply sort the abstracts by a tag such as "Suspected AE" or "Identifiable Patient":
The ranking is preserved once users start reviewing articles in the detail page: users will screen the prioritized articles first.
Abstracts not tagged can in principle receive less scrutiny during reviews. Examples of how this can be done:
- Update your screening process so that the "Not Suspected AE" abstracts receive fewer QC steps (ie. "sampled" QC)
For example: In an ICSR workflow, Batch Review can be used to refute all animal/in vitro studies at once (typically not a valid ICSR):
- From the search box, select articles tagged as Animal/In Vitro with
- Then click "Batch Review" to quickly review all abstracts from the same screen, according to the search criteria specified
- Use the checkbox to select irrelevant articles and save your decision for all selections at once
You can also use the
notag:option to search for the absence of a given tag.
notag:adversereturns all articles without the "Suspected AE" tag.
Users can further reduce effort by configuring monitors to automatically pre-screen abstracts based on AI tags.
- All pre-screened articles remain visible in the results. They are presented in the "Reviewed" tab and can still be reviewed as part of the quality control process.
In the Monitor configuration screen users can select the level of pre-screening for a given Monitor according to which AI tags are present in an article:
Screening automation options during Monitor configuration